Journal article
Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs
EB King, RK Shepherd, DJ Brown, JB Fallon
JARO Journal of the Association for Research in Otolaryngology | SPRINGER | Published : 2017
Abstract
Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Ménière’s disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs. Vestibular and cochlea function were assessed by recording short latency vestib..
View full abstractGrants
Awarded by Garnett Passe and Rodney Williams Memorial Foundation
Funding Acknowledgements
This study was funded by the Garnett Passe & Rodney Williams Memorial Foundation. This authors wish to thank Mr. Rodney Millard, Mr. Mark Harrison, and Dr. Mohit Shivdasani from the Bionics Institute and Professor Ian Curthoys from the University of Sydney for their input into setting up the VsEP recording equipment at the Bionics Institute; Professor Alec Salt from Washington University School of Medicine, St Louis, USA, for technical advice; Ms. Shefin George from the Bionics Institute for her assistance with perfusions; and Miss Prudence Neilson from University of Melbourne for preparing histology slides. The time invested by A/Prof Fallon, Prof Shepherd, Dr. Brown were supported by research grants from the NHMRC (GNT1081478) and the Garnett Passe and Rodney Williams Memorial Foundation.